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Brand name: rosiglitazone
Generic name: avandia, Rosiglitazone
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Compared to patients receiving placebo, patients with congestive heart failure (CHF) receiving rosiglitazone also experienced more cardiovascular deaths, more CHF worsening, more new or worsening dyspnea, more increases in CHF medication and cardiovascular hospitalization, more myocardial infarctions, and angina. No increase in fracture rates was observed in men treated with rosiglitazone. New onset or worsening (diabetic) macular edema with decreased visual acuity has been reported very rarely in postmarketing experience with rosiglitazone. Overall, the types of adverse reactions without regard to causality reported when rosiglitazone was used in combination with metformin were similar to those reported during monotherapy with rosiglitazone. White blood cell counts also decreased slightly in adult patients treated with rosiglitazone. The ALT elevations in patients treated with rosiglitazone were reversible.

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